InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB20

Summary

InnateDB Protein

IDBP-50736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB20

Protein Name

RAB20, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000267328

InnateDB Gene

IDBG-50734 (RAB20)

Protein Structure

UniProt Annotation

Function

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000269PubMed:21255211}.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). {ECO:0000269PubMed:16613320}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0090383	phagosome acidification
GO:0090385	phagosome-lysosome fusion

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt