InnateDB Protein
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IDBP-50772.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZDHHC21
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Protein Name
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zinc finger, DHHC-type containing 21
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370303
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InnateDB Gene
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IDBG-50770 (ZDHHC21)
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Protein Structure
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Function |
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001594
Zinc finger, DHHC-type, palmitoyltransferase
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PFAM |
PF01529
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IVQ6
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PhosphoSite |
PhosphoSite-Q8IVQ6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
340481
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UniGene |
Hs.740511
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RefSeq |
NP_848661
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HUGO |
HGNC:20750
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OMIM |
614605
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CCDS |
CCDS6475
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HPRD |
15716
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IMGT |
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EMBL |
AK292960
AL390732
BC042558
CH471071
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GenPept |
AAH42558
BAF85649
CAH73849
EAW58692
EAW58693
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