Version 5.4
Homo sapiens Protein: ESYT2
Summary
InnateDB Protein IDBP-51203.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESYT2
Protein Name extended synaptotagmin-like protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000251527
InnateDB Gene IDBG-51201 (ESYT2)
Protein Structure
UniProt Annotation
Function Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. {ECO:0000269PubMed:17360437, ECO:0000269PubMed:20833364, ECO:0000269PubMed:23791178, ECO:0000269PubMed:24847877}.
Subcellular Localization Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain.
Disease Associations
Tissue Specificity Widely expressed with high level in cerebellum. {ECO:0000269PubMed:17360437}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008429 phosphatidylethanolamine binding
GO:0031210 phosphatidylcholine binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006869 lipid transport
GO:0006897 endocytosis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0044232 organelle membrane contact site
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0FGR8
PhosphoSite PhosphoSite-A0FGR8
TrEMBL
UniProt Splice Variant
Entrez Gene 57488
UniGene Hs.649908
RefSeq NP_065779
HUGO HGNC:22211
OMIM
CCDS CCDS34791
HPRD 13053
IMGT
EMBL AB033054 AJ303365 AK001181 AK124091 AK126214 AL833233 AY368150 BC013957 CH236954 DQ993201
GenPept AAH13957 AAR89381 ABJ97706 BAA86542 BAA91539 BAC85769 BAC86489 CAC33887 CAH10642 EAL23931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca