InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSIP1

Summary

InnateDB Protein

IDBP-51339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSIP1

Protein Name

PC4 and SFRS1 interacting protein 1

Synonyms

DFS70; LEDGF; p52; p75; PAIP; PSIP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000370114

InnateDB Gene

IDBG-51337 (PSIP1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269PubMed:15642333}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.

Disease Associations

Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.

Tissue Specificity

Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9822615}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0033613	activating transcription factor binding
GO:0044822	poly(A) RNA binding
GO:0097100	supercoiled DNA binding

Biological Process

GO:0000395	mRNA 5'-splice site recognition
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0016032	viral process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005720	nuclear heterochromatin
GO:0005829	cytosol
GO:0034399	nuclear periphery
GO:0035327	transcriptionally active chromatin