InnateDB Protein
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IDBP-51343.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSIP1
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Protein Name
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PC4 and SFRS1 interacting protein 1
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Synonyms
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DFS70; LEDGF; p52; p75; PAIP; PSIP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370092
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InnateDB Gene
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IDBG-51337 (PSIP1)
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Protein Structure
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Function |
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269PubMed:15642333}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
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Disease Associations |
Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
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Tissue Specificity |
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9822615}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
48
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
1
[view]
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000313
PWWP domain
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PFAM |
PF00855
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PRINTS |
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PIRSF |
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SMART |
SM00293
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TIGRFAMs |
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Modification |
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SwissProt |
O75475
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PhosphoSite |
PhosphoSite-O75475
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TrEMBL |
Q8N4N4
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UniProt Splice Variant |
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Entrez Gene |
11168
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UniGene |
Hs.575668
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RefSeq |
XP_005251413
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HUGO |
HGNC:9527
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OMIM |
603620
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CCDS |
CCDS6480
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HPRD |
04688
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IMGT |
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EMBL |
AF063020
AF098482
AF098483
AF199339
AF432220
AL359998
AL441925
AL513423
BC033817
BC044568
BC064135
CH471071
U94319
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GenPept |
AAB52589
AAC25167
AAC97945
AAC97946
AAF25870
AAF25871
AAH33817
AAH44568
AAH64135
AAL99926
CAH71355
CAI13287
EAW58675
EAW58677
EAW58678
EAW58679
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