Homo sapiens Protein: PSIP1
InnateDB Protein IDBP-51345.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSIP1
Protein Name PC4 and SFRS1 interacting protein 1
Synonyms DFS70; LEDGF; p52; p75; PAIP; PSIP2;
Species Homo sapiens
Ensembl Protein ENSP00000370091
InnateDB Gene IDBG-51337 (PSIP1)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269PubMed:15642333}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
Disease Associations Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
Tissue Specificity Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9822615}.
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
RNA-RNA 1 [view]
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0033613 activating transcription factor binding
GO:0044822 poly(A) RNA binding
GO:0097100 supercoiled DNA binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0016032 viral process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0075713 establishment of integrated proviral latency
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005720 nuclear heterochromatin
GO:0005829 cytosol
GO:0034399 nuclear periphery
GO:0035327 transcriptionally active chromatin
Protein Structure and Domains
InterPro IPR000313 PWWP domain
PFAM PF00855
Post-translational Modifications
SwissProt O75475
PhosphoSite PhosphoSite-O75475
UniProt Splice Variant
Entrez Gene 11168
UniGene Hs.575668
RefSeq XP_005251415
OMIM 603620
HPRD 04688
EMBL AF063020 AF098482 AF098483 AF199339 AF432220 AL359998 AL441925 AL513423 BC033817 BC044568 BC064135 CH471071 U94319
GenPept AAB52589 AAC25167 AAC97945 AAC97946 AAF25870 AAF25871 AAH33817 AAH44568 AAH64135 AAL99926 CAH71355 CAI13287 EAW58675 EAW58677 EAW58678 EAW58679