Version 5.4
Homo sapiens Protein: HIPK4
Summary
InnateDB Protein IDBP-51425.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIPK4
Protein Name homeodomain interacting protein kinase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000291823
InnateDB Gene IDBG-51423 (HIPK4)
Protein Structure
UniProt Annotation
Function Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0046777 protein autophosphorylation
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NE63
PhosphoSite PhosphoSite-Q8NE63
TrEMBL B4DWX2
UniProt Splice Variant
Entrez Gene 147746
UniGene Hs.79363
RefSeq NP_653286
HUGO HGNC:19007
OMIM 611712
CCDS CCDS12555
HPRD 13652
IMGT
EMBL AK057380 AK292228 AK301713 BC034501
GenPept AAH34501 BAB71458 BAF84917 BAG63184

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca