InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBXN1

Summary

InnateDB Protein

IDBP-51559.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBXN1

Protein Name

UBX domain protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000294119

InnateDB Gene

IDBG-51555 (UBXN1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	105 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031593	polyubiquitin binding
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding
GO:0051117	ATPase binding
GO:0071796	K6-linked polyubiquitin binding

Biological Process

GO:0031397	negative regulation of protein ubiquitination
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0034098	Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR001012 UBX domain
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00789

PRINTS

PIRSF

SMART

SM00166
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q04323