Version 5.4
Homo sapiens Protein: COA3
Summary
InnateDB Protein IDBP-51715.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COA3
Protein Name coiled-coil domain containing 56
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354762
InnateDB Gene IDBG-51713 (COA3)
Protein Structure
UniProt Annotation
Function Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. {ECO:0000269PubMed:23260140}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:23260140}; Single-pass membrane protein {ECO:0000269PubMed:23260140}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0033617 mitochondrial respiratory chain complex IV assembly
GO:0070131 positive regulation of mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0031305 integral component of mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR018628 Coiled-coil domain-containing protein 56
PFAM PF09813
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2R0
PhosphoSite PhosphoSite-Q9Y2R0
TrEMBL K7EPV0
UniProt Splice Variant
Entrez Gene 28958
UniGene Hs.16059
RefSeq NP_001035521
HUGO HGNC:24990
OMIM 614775
CCDS CCDS32660
HPRD
IMGT
EMBL AC016889 AC100793 AF070665 AK290863 BC002698 CH471152
GenPept AAD20971 AAH02698 BAF83552 EAW60884 EAW60885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca