InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIN

Summary

InnateDB Protein

IDBP-51976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIN

Protein Name

KIN, antigenic determinant of recA protein homolog (mouse)

Synonyms

BTCD; KIN17; Rts2;

Species

Homo sapiens

Ensembl Protein

ENSP00000368881

InnateDB Gene

IDBG-51974 (KIN)

Protein Structure

UniProt Annotation

Function

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250UniProtKB:Q8K339, ECO:0000269PubMed:11880372, ECO:0000269PubMed:12359749, ECO:0000269PubMed:12754299, ECO:0000269PubMed:12853634, ECO:0000269PubMed:15831485, ECO:0000269PubMed:17045609}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11880372, ECO:0000269PubMed:12359749, ECO:0000269PubMed:12754299, ECO:0000269PubMed:12853634, ECO:0000269PubMed:15831485}. Cytoplasm {ECO:0000269PubMed:11880372, ECO:0000269PubMed:12359749, ECO:0000269PubMed:12754299, ECO:0000269PubMed:12853634, ECO:0000269PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250UniProtKB:Q8K339, ECO:0000269PubMed:11880372, ECO:0000269PubMed:12359749, ECO:0000269PubMed:12754299, ECO:0000269PubMed:12853634, ECO:0000269PubMed:15831485}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). {ECO:0000269PubMed:10964102, ECO:0000269PubMed:9266022}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006397	mRNA processing
GO:0006974	cellular response to DNA damage stimulus
GO:0016032	viral process