InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDX4

Summary

InnateDB Protein

IDBP-52047.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX4

Protein Name

peroxiredoxin 4

Synonyms

AOE37-2; AOE372; HEL-S-97n; PRX-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000368646

InnateDB Gene

IDBG-52043 (PRDX4)

Protein Structure

UniProt Annotation

Function

Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269PubMed:9388242}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9388242}. Secreted {ECO:0000269PubMed:9388242}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.

Experimentally validated
Total	65 [view]
Protein-Protein	64 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0007252	I-kappaB phosphorylation
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0019471	4-hydroxyproline metabolic process
GO:0022417	protein maturation by protein folding
GO:0030198	extracellular matrix organization
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:2000255	negative regulation of male germ cell proliferation

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005790	smooth endoplasmic reticulum
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal

PFAM