InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNRPA

Summary

InnateDB Protein

IDBP-52149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPA

Protein Name

small nuclear ribonucleoprotein polypeptide A

Synonyms

Mud1; U1-A; U1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000243563

InnateDB Gene

IDBG-52147 (SNRPA)

Protein Structure

UniProt Annotation

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269PubMed:9848648}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	83 [view]
Protein-DNA	10 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017069	snRNA binding
GO:0044822	poly(A) RNA binding