InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RRAGA

Summary

InnateDB Protein

IDBP-52350.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRAGA

Protein Name

Ras-related GTP binding A

Synonyms

FIP-1; FIP1; RAGA;

Species

Homo sapiens

Ensembl Protein

ENSP00000369899

InnateDB Gene

IDBG-52348 (RRAGA)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269PubMed:20381137, ECO:0000269PubMed:8995684, ECO:0000269PubMed:9394008}.

Subcellular Localization

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. {ECO:0000269PubMed:8995684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0006915	apoptotic process
GO:0007264	small GTPase mediated signal transduction
GO:0008219	cell death
GO:0019048	modulation by virus of host morphology or physiology
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0045919	positive regulation of cytolysis
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670

PRINTS

PR00449
PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7L523