Version 5.4
Homo sapiens Protein: HRASLS2
Summary
InnateDB Protein IDBP-52533.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRASLS2
Protein Name HRAS-like suppressor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000255695
InnateDB Gene IDBG-52531 (HRASLS2)
Protein Structure
UniProt Annotation
Function Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC. {ECO:0000269PubMed:19615464}.
Subcellular Localization Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.
Disease Associations
Tissue Specificity Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183). {ECO:0000269PubMed:18163183, ECO:0000269PubMed:19615464}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016746 transferase activity, transferring acyl groups
GO:0016787 hydrolase activity
Biological Process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007053 LRAT-like domain
PFAM PF04970
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWW9
PhosphoSite PhosphoSite-Q9NWW9
TrEMBL
UniProt Splice Variant
Entrez Gene 54979
UniGene
RefSeq NP_060348
HUGO HGNC:17824
OMIM 613866
CCDS CCDS8046
HPRD 13670
IMGT
EMBL AB453251 AK000563 CH471076
GenPept BAA91256 BAH22445 EAW74157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca