InnateDB Protein
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IDBP-52533.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HRASLS2
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Protein Name
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HRAS-like suppressor 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000255695
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InnateDB Gene
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IDBG-52531 (HRASLS2)
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Protein Structure
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Function |
Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC. {ECO:0000269PubMed:19615464}.
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Subcellular Localization |
Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183). {ECO:0000269PubMed:18163183, ECO:0000269PubMed:19615464}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0016746
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transferase activity, transferring acyl groups
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GO:0016787
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hydrolase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007053
LRAT-like domain
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PFAM |
PF04970
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NWW9
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PhosphoSite |
PhosphoSite-Q9NWW9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54979
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UniGene |
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RefSeq |
NP_060348
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HUGO |
HGNC:17824
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OMIM |
613866
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CCDS |
CCDS8046
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HPRD |
13670
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IMGT |
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EMBL |
AB453251
AK000563
CH471076
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GenPept |
BAA91256
BAH22445
EAW74157
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