InnateDB Protein
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IDBP-52602.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RTN3
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Protein Name
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reticulon 3
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Synonyms
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ASYIP; HAP; NSPL2; NSPLII; RTN3-A1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344106
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InnateDB Gene
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IDBG-52600 (RTN3)
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Protein Structure
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Function |
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. {ECO:0000269PubMed:15286784, ECO:0000269PubMed:16054885, ECO:0000269PubMed:17031492, ECO:0000269PubMed:17191123}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. {ECO:0000269PubMed:10331947, ECO:0000269PubMed:12811824, ECO:0000269PubMed:14986927, ECO:0000269PubMed:15286784, ECO:0000269PubMed:15946766}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003388
Reticulon
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PFAM |
PF02453
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95197
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PhosphoSite |
PhosphoSite-O95197
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10313
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UniGene |
Hs.743229
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RefSeq |
NP_958831
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HUGO |
HGNC:10469
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OMIM |
604249
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CCDS |
CCDS8050
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HPRD |
18516
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IMGT |
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EMBL |
AB209771
AF059524
AF059525
AF059526
AF059527
AF059528
AF059529
AF119297
AK075412
AK222898
AK295361
AK297529
AP000753
AP006289
AY427821
AY750848
BC000634
BC010556
BC011394
BC022993
BC100822
BC100823
BC105981
BC105982
BC118550
BC118628
BK001681
BK001684
BK001685
CH471076
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GenPept |
AAC99319
AAD20951
AAD26810
AAH00634
AAH10556
AAH11394
AAH22993
AAI00823
AAI00824
AAI05982
AAI05983
AAI18551
AAI18629
AAR02474
AAU81930
BAD93008
BAD96618
BAG52134
BAH12044
BAH12606
DAA01931
DAA01941
DAA01943
EAW74170
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