InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RTN3

Summary

InnateDB Protein

IDBP-52610.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RTN3

Protein Name

reticulon 3

Synonyms

ASYIP; HAP; NSPL2; NSPLII; RTN3-A1;

Species

Homo sapiens

Ensembl Protein

ENSP00000340903

InnateDB Gene

IDBG-52600 (RTN3)

Protein Structure

UniProt Annotation

Function

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. {ECO:0000269PubMed:15286784, ECO:0000269PubMed:16054885, ECO:0000269PubMed:17031492, ECO:0000269PubMed:17191123}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. {ECO:0000269PubMed:10331947, ECO:0000269PubMed:12811824, ECO:0000269PubMed:14986927, ECO:0000269PubMed:15286784, ECO:0000269PubMed:15946766}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	16 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0071786	endoplasmic reticulum tubular network organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome