Version 5.4
Homo sapiens Protein: B3GNT8
Summary
InnateDB Protein IDBP-53060.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3GNT8
Protein Name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312700
InnateDB Gene IDBG-53058 (B3GNT8)
Protein Structure
UniProt Annotation
Function Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans. {ECO:0000269PubMed:15620693, ECO:0000269PubMed:15917431}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250UniProtKB:Q9NY97}; Single-pass type II membrane protein {ECO:0000250UniProtKB:Q9NY97}.
Disease Associations
Tissue Specificity Highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, and ileum, and weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, and testis. Not detected in colon. Differentially expressed in human tumor cell lines. {ECO:0000269PubMed:15486459, ECO:0000269PubMed:15620693}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0016262 protein N-acetylglucosaminyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0016266 O-glycan processing
GO:0030311 poly-N-acetyllactosamine biosynthetic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002659 Glycosyl transferase, family 31
PFAM PF01762
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z7M8
PhosphoSite PhosphoSite-Q7Z7M8
TrEMBL
UniProt Splice Variant
Entrez Gene 374907
UniGene Hs.693514
RefSeq NP_940942
HUGO HGNC:24139
OMIM 615357
CCDS CCDS12582
HPRD 12510
IMGT
EMBL AB175895 AJ419172 AY277592
GenPept AAP34405 BAD86525 CAD11601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca