InnateDB Protein
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IDBP-53105.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPARGC1B
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Protein Name
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peroxisome proliferator-activated receptor gamma, coactivator 1 beta
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353638
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InnateDB Gene
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IDBG-53101 (PPARGC1B)
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Protein Structure
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Function |
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269PubMed:11854298, ECO:0000269PubMed:12678921, ECO:0000269PubMed:15546003, ECO:0000269PubMed:23836911}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11854298}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous with higher expression in heart, brain and skeletal muscle. {ECO:0000269PubMed:11854298, ECO:0000269PubMed:12678921}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
5
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030520
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intracellular estrogen receptor signaling pathway
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:2000273
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positive regulation of receptor activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q86YN6
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PhosphoSite |
PhosphoSite-Q86YN6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
133522
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UniGene |
Hs.483816
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RefSeq |
NP_001166169
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HUGO |
HGNC:30022
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OMIM |
608886
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CCDS |
CCDS54933
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HPRD |
10594
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IMGT |
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EMBL |
AC008545
AC022100
AF468496
AF468497
AK095391
AK123614
AY188947
AY188948
AY188949
AY188950
BC132971
BC132973
CH471062
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GenPept |
AAI32972
AAI32974
AAL78633
AAL78634
AAO40022
AAO40023
AAO40024
AAO40025
BAC04541
BAG53922
EAW61759
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