InnateDB Protein
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IDBP-531508.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Inpp5e
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Protein Name
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inositol polyphosphate-5-phosphatase E
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Synonyms
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1200002L24Rik; 72kDa; mKIAA0123;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000119485
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InnateDB Gene
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IDBG-149167 (Inpp5e)
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Protein Structure
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Function |
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates. {ECO:0000269PubMed:10806194}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein associated with Golgi stacks.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis, in pachytene and diplotene spermatocytes, but not in more mature elongating spermatids. Detected in neurons throughout the brain. {ECO:0000269PubMed:10806194}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004439
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phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927753
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InterPro |
IPR000300
Inositol polyphosphate-related phosphatase
IPR005135
Endonuclease/exonuclease/phosphatase
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PFAM |
PF03372
PF14529
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PRINTS |
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PIRSF |
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SMART |
SM00128
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JII1
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PhosphoSite |
PhosphoSite-Q9JII1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64436
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UniGene |
Mm.487781
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RefSeq |
NP_149125
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MGI ID |
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MGI Symbol |
Inpp5e
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OMIM |
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CCDS |
CCDS15805
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HPRD |
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IMGT |
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EMBL |
AF226683
AK080075
AK154097
AK170786
BC052717
BC080295
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GenPept |
AAF86957
AAH52717
AAH80295
BAC37823
BAE32374
BAE42028
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