Version 5.4
Mus musculus Protein: Ror2
Summary
InnateDB Protein IDBP-531737.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ror2
Protein Name receptor tyrosine kinase-like orphan receptor 2
Synonyms mRor2; Ntrkr2;
Species Mus musculus
Ensembl Protein ENSMUSP00000123362
InnateDB Gene IDBG-152934 (Ror2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017147 Wnt-protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001756 somitogenesis
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007254 JNK cascade
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030538 embryonic genitalia morphogenesis
GO:0042472 inner ear morphogenesis
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1347521
InterPro IPR000001 Kringle
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013806 Kringle-like fold
IPR016247 Tyrosine-protein kinase, receptor ROR
IPR020067 Frizzled domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00051
PF00069
PF07714
PF07679
PF07686
PF00047
PF01392
PRINTS PR00109
PIRSF PIRSF000624
SMART SM00130
SM00220
SM00408
SM00409
SM00063
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PUN5
UniProt Splice Variant
Entrez Gene 26564
UniGene Mm.342774
RefSeq
MGI ID
MGI Symbol Ror2
OMIM
CCDS
HPRD
IMGT
EMBL AC111017
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca