InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med28

Summary

InnateDB Protein

IDBP-531842.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med28

Protein Name

mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)

Synonyms

1500003D12Rik; AI451633; AU045690; Eg1; FKSG20; magicin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115882

InnateDB Gene

IDBG-162461 (Med28)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=May be also cytoplasmic and membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0019827	stem cell maintenance
GO:0051151	negative regulation of smooth muscle cell differentiation