Version 5.4
Mus musculus Protein: Spata13
Summary
InnateDB Protein IDBP-532080.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spata13
Protein Name spermatogenesis associated 13
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000123928
InnateDB Gene IDBG-170680 (Spata13)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000250, ECO:0000269PubMed:19893577}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. {ECO:0000250}.
Disease Associations
Tissue Specificity Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269PubMed:19893577}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030334 regulation of cell migration
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0032587 ruffle membrane
Protein Structure and Domains
PDB ID MGI:104838
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF00169
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5DU57
PhosphoSite PhosphoSite-Q5DU57
TrEMBL E9Q3I3
UniProt Splice Variant
Entrez Gene 219140
UniGene Mm.404006
RefSeq XP_006518930
MGI ID
MGI Symbol Spata13
OMIM
CCDS CCDS49516
HPRD
IMGT
EMBL AC114000 AC151835 AK158193 AK220313
GenPept BAD90389 BAE34401

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca