InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ciapin1

Summary

InnateDB Protein

IDBP-532122.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ciapin1

Protein Name

cytokine induced apoptosis inhibitor 1

Synonyms

2810413N20Rik; AA617265; anamorsin; AU021794;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125451

InnateDB Gene

IDBG-182674 (Ciapin1)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1 (By similarity). Has anti- apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. {ECO:0000255HAMAP-Rule:MF_03115, ECO:0000269PubMed:14970183}.

Subcellular Localization

Cytoplasm. Nucleus. Mitochondrion intermembrane space {ECO:0000255HAMAP-Rule:MF_03115}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding