InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plekha2

Summary

InnateDB Protein

IDBP-532142.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekha2

Protein Name

pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2

Synonyms

6430512N22Rik; AI851530; AU041791; TAPP2; W91773;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122564

InnateDB Gene

IDBG-143454 (Plekha2)

Protein Structure

UniProt Annotation

Function

Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269PubMed:12101241, ECO:0000269PubMed:14516276}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12101241}. Cell membrane {ECO:0000269PubMed:12101241}; Peripheral membrane protein {ECO:0000269PubMed:12101241}. Nucleus {ECO:0000269PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0030165	PDZ domain binding
GO:0043236	laminin binding