Version 5.4
Mus musculus Protein: Tlcd1
Summary
InnateDB Protein IDBP-532515.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tlcd1
Protein Name TLC domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000114202
InnateDB Gene IDBG-202299 (Tlcd1)
Protein Structure
UniProt Annotation
Function Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915572
InterPro IPR006634 TRAM/LAG1/CLN8 homology domain
PFAM PF03798
PRINTS
PIRSF
SMART SM00724
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99JT6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 68385
UniGene
RefSeq NP_080984
MGI ID
MGI Symbol Tlcd1
OMIM
CCDS CCDS25092
HPRD
IMGT
EMBL AK002703 AK046577 AK161721 AK165432 AL591070 BC005702 BC039182
GenPept AAH05702 AAH39182 BAB22297 BAE20654 BAE36548 BAE38185 CAI24331 CAI24332 CAI24333 CAI24334

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca