InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hyou1

Summary

InnateDB Protein

IDBP-533199.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hyou1

Protein Name

hypoxia up-regulated 1

Synonyms

AI415631; Cab140; CBP-140; Grp170; Orp150;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125594

InnateDB Gene

IDBG-157064 (Hyou1)

Protein Structure

UniProt Annotation

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000269PubMed:7641295}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding

Biological Process

GO:0000902	cell morphogenesis
GO:0002931	response to ischemia

Cellular Component

GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:108030

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JKR6