InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prdx1

Summary

InnateDB Protein

IDBP-533245.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdx1

Protein Name

peroxiredoxin 1

Synonyms

MSP23; NkefA; OSF-3; OSF3; PAG; Paga; PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117007

InnateDB Gene

IDBG-178542 (Prdx1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0006979	response to oxidative stress
GO:0008283	cell proliferation
GO:0019430	removal of superoxide radicals
GO:0032872	regulation of stress-activated MAPK cascade
GO:0034101	erythrocyte homeostasis
GO:0042267	natural killer cell mediated cytotoxicity
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005719	nuclear euchromatin
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005782	peroxisomal matrix
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:99523

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin

PFAM

PF00578
PF13098
PF13192
PF13462
PF13905
PF08534

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AXW4

UniProt Splice Variant

Entrez Gene

18477

UniGene

Mm.471800

RefSeq

MGI ID

MGI Symbol

Prdx1

OMIM

CCDS

HPRD

IMGT

EMBL

AL831786

GenPept