Version 5.4
Homo sapiens Protein: PPP1R14B
Summary
InnateDB Protein IDBP-53331.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R14B
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 14B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310117
InnateDB Gene IDBG-53329 (PPP1R14B)
Protein Structure
UniProt Annotation
Function Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Expressed at low levels. {ECO:0000269PubMed:8838322}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0042325 regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008025 PKC-activated phosphatase-1 inhibitor
PFAM PF05361
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96C90
PhosphoSite PhosphoSite-Q96C90
TrEMBL F5GXC4
UniProt Splice Variant
Entrez Gene 26472
UniGene
RefSeq NP_619634
HUGO HGNC:9057
OMIM 601140
CCDS CCDS31596
HPRD 18513
IMGT
EMBL AP001453 BC014522 BC094817 BT009914 CH471076
GenPept AAH14522 AAH94817 AAP88916 EAW74226 EAW74227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca