InnateDB Protein
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IDBP-53344.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHPT1
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Protein Name
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choline phosphotransferase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000229266
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InnateDB Gene
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IDBG-53342 (CHPT1)
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Protein Structure
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Function |
Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000269PubMed:12221122}; Multi-pass membrane protein {ECO:0000269PubMed:12221122}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines. {ECO:0000269PubMed:10893425, ECO:0000269PubMed:12359261}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004142
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diacylglycerol cholinephosphotransferase activity
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GO:0016780
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phosphotransferase activity, for other substituted phosphate groups
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GO:0019992
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diacylglycerol binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000462
CDP-alcohol phosphatidyltransferase
IPR014472
Choline/ethanolamine phosphotransferase
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PFAM |
PF01066
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PRINTS |
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PIRSF |
PIRSF015665
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WUD6
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PhosphoSite |
PhosphoSite-Q8WUD6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56994
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UniGene |
Hs.577786
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RefSeq |
NP_064629
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HUGO |
HGNC:17852
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OMIM |
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CCDS |
CCDS9086
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HPRD |
13052
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IMGT |
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EMBL |
AF047431
AF111803
AF195623
AF195624
AK075211
AY166717
AY166718
AY280609
AY280610
AY294627
BC020819
BC050429
CH471054
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GenPept |
AAD44019
AAF87947
AAF87948
AAH20819
AAH50429
AAL39005
AAN86122
AAN86123
AAP34412
AAP34413
AAP37157
BAG52084
EAW97675
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