Version 5.4
Mus musculus Protein: Dab2
Summary
InnateDB Protein IDBP-533779.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dab2
Protein Name disabled homolog 2 (Drosophila)
Synonyms 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; Doc-2; Doc2; p96;
Species Mus musculus
Ensembl Protein ENSMUSP00000125696
InnateDB Gene IDBG-128034 (Dab2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0035615 clathrin adaptor activity
GO:0038024 cargo receptor activity
GO:0046332 SMAD binding
Biological Process
GO:0000904 cell morphogenesis involved in differentiation
GO:0001701 in utero embryonic development
GO:0006898 receptor-mediated endocytosis
GO:0006907 pinocytosis
GO:0007492 endoderm development
GO:0007588 excretion
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
GO:2000370 positive regulation of clathrin-mediated endocytosis
GO:2000643 positive regulation of early endosome to late endosome transport
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016324 apical plasma membrane
GO:0070022 transforming growth factor beta receptor homodimeric complex
Protein Structure and Domains
PDB ID MGI:109175
InterPro IPR006020 PTB/PI domain
PFAM PF00640
PF14719
PRINTS
PIRSF
SMART SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CZ53
UniProt Splice Variant
Entrez Gene 13132
UniGene Mm.488345
RefSeq
MGI ID
MGI Symbol Dab2
OMIM
CCDS
HPRD
IMGT
EMBL AC099884 AC105324
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca