InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med6

Summary

InnateDB Protein

IDBP-533854.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med6

Protein Name

mediator of RNA polymerase II transcription, subunit 6 homolog (yeast)

Synonyms

1500012F11Rik; AU019660; AV213303;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125156

InnateDB Gene

IDBG-154516 (Med6)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

MGI:1917042

InterPro

IPR007018 Mediator complex, subunit Med6
IPR016820 Mediator complex, subunit Med6, metazoa/plant

PFAM

PF04934

PRINTS

PIRSF

PIRSF023869

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q921D4

PhosphoSite

PhosphoSite-

TrEMBL

E0CXQ3

UniProt Splice Variant

Entrez Gene

69792

UniGene

RefSeq

XP_006516274

MGI ID

MGI Symbol

Med6

OMIM

CCDS

HPRD

IMGT

EMBL

AC154908 AK089101 AK171784 BC013096

GenPept

AAH13096 BAC40749 BAE42663