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InnateDB Protein
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IDBP-533870.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Timm22
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Protein Name
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translocase of inner mitochondrial membrane 22 homolog (yeast)
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Synonyms
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Tim22;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000123281
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InnateDB Gene
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IDBG-200913 (Timm22)
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Protein Structure
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| Function |
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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| PDB ID |
MGI:1929742
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
Z4YN86
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| UniProt Splice Variant |
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| Entrez Gene |
56322
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| UniGene |
Mm.18803
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| RefSeq |
NP_075844
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| MGI ID |
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| MGI Symbol |
Timm22
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL663050
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| GenPept |
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Version 5.4