Version 5.4
Mus musculus Protein: Mlxipl
Summary
InnateDB Protein IDBP-534024.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlxipl
Protein Name MLX interacting protein-like
Synonyms bHLHd14; ChREBP; Wbscr14; WS-bHLH;
Species Mus musculus
Ensembl Protein ENSMUSP00000121348
InnateDB Gene IDBG-203540 (Mlxipl)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity Expressed in the ventricular and intermediate zones of the developing spinal cord of E12.5 embryos. In later embryos expressed in a variety of tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035538 carbohydrate response element binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0010255 glucose mediated signaling pathway
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0042593 glucose homeostasis
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055089 fatty acid homeostasis
GO:0071157 negative regulation of cell cycle arrest
GO:0090324 negative regulation of oxidative phosphorylation
GO:2000505 regulation of energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1927999
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MZ3
PhosphoSite PhosphoSite-Q99MZ3
TrEMBL
UniProt Splice Variant
Entrez Gene 58805
UniGene Mm.34213
RefSeq
MGI ID 4GNT
MGI Symbol Mlxipl
OMIM
CCDS
HPRD
IMGT
EMBL AF156604 AF245475 AF245476 AF245477 AF245478 AF245479
GenPept AAF68175 AAK20940 AAK20941 AAK20942 AAK20943 AAK20944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca