Version 5.4
Mus musculus Protein: Vps51
Summary
InnateDB Protein IDBP-534753.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps51
Protein Name RIKEN cDNA 1110014N23 gene
Synonyms 1110014N23Rik; 3110057M17Rik; AI837850; Ffr;
Species Mus musculus
Ensembl Protein ENSMUSP00000123857
InnateDB Gene IDBG-134384 (Vps51)
Protein Structure
UniProt Annotation
Function Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy (By similarity). VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006869 lipid transport
GO:0006914 autophagy
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0000938 GARP complex
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:1915755
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UVL4
PhosphoSite PhosphoSite-Q3UVL4
TrEMBL
UniProt Splice Variant
Entrez Gene 68505
UniGene Mm.227361
RefSeq
MGI ID
MGI Symbol Vps51
OMIM
CCDS
HPRD
IMGT
EMBL AC131692 AK014229 AK137155 AK146211 BC118930 BC118931 CH466612
GenPept AAI18931 AAI18932 BAB29217 BAE23255 BAE26981 EDL33203

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca