InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNB1

Summary

InnateDB Protein

IDBP-53487.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNB1

Protein Name

interferon, beta 1, fibroblast

Synonyms

IFB; IFF; IFNB;

Species

Homo sapiens

Ensembl Protein

ENSP00000369581

InnateDB Gene

IDBG-53485 (IFNB1)

Protein Structure

UniProt Annotation

Function

Has antiviral, antibacterial and anticancer activities.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	6 [view]
Protein-DNA	39 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002312	B cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0030101	natural killer cell activation
GO:0030183	B cell differentiation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458	cellular response to interferon-beta
GO:0042100	B cell proliferation
GO:0042742	defense response to bacterium
GO:0043330	response to exogenous dsRNA
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0045343	regulation of MHC class I biosynthetic process
GO:0045581	negative regulation of T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0071359	cellular response to dsRNA
GO:0071360	cellular response to exogenous dsRNA
GO:2000552	negative regulation of T-helper 2 cell cytokine production
GO:2001235	positive regulation of apoptotic signaling pathway