Version 5.4
Mus musculus Protein: Pqlc2
Summary
InnateDB Protein IDBP-535421.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pqlc2
Protein Name PQ loop repeat containing 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000121362
InnateDB Gene IDBG-200327 (Pqlc2)
Protein Structure
UniProt Annotation
Function Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000250}.
Subcellular Localization Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:23169667}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015181 arginine transmembrane transporter activity
GO:0015189 L-lysine transmembrane transporter activity
GO:0015326 cationic amino acid transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0015809 arginine transport
GO:0015819 lysine transport
GO:0080144 amino acid homeostasis
Cellular Component
GO:0005765 lysosomal membrane
GO:0031301 integral component of organelle membrane
Protein Structure and Domains
PDB ID MGI:2384837
InterPro IPR006603 PQ-loop repeat
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF04193
PRINTS
PIRSF
SMART SM00679
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C4N4
PhosphoSite PhosphoSite-
TrEMBL F6QNQ2
UniProt Splice Variant
Entrez Gene 212555
UniGene Mm.483700
RefSeq
MGI ID
MGI Symbol Pqlc2
OMIM
CCDS CCDS18843
HPRD
IMGT
EMBL AK081661 AK156668 AL807811 BC025609
GenPept AAH25609 BAC38282 BAE33801 CAM18542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca