InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmna

Summary

InnateDB Protein

IDBP-535445.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmna

Protein Name

lamin A

Synonyms

Dhe;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120784

InnateDB Gene

IDBG-160992 (Lmna)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	68 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006997	nucleus organization
GO:0006998	nuclear envelope organization
GO:0007517	muscle organ development
GO:0034504	protein localization to nucleus
GO:0035105	sterol regulatory element binding protein import into nucleus
GO:0055015	ventricular cardiac muscle cell development
GO:0071456	cellular response to hypoxia
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0090343	positive regulation of cell aging
GO:1900180	regulation of protein localization to nucleus
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005638	lamin filament
GO:0005882	intermediate filament
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:96794

InterPro

IPR001664 Intermediate filament protein

PFAM

PF00038

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YUF7

UniProt Splice Variant

Entrez Gene

16905

UniGene

Mm.488848

RefSeq

MGI ID

MGI Symbol

Lmna

OMIM

CCDS

HPRD

IMGT

EMBL

AC102388 AC145168

GenPept