Version 5.4
Mus musculus Protein: Mpv17l
Summary
InnateDB Protein IDBP-535484.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mpv17l
Protein Name Mpv17 transgene, kidney disease mutant-like
Synonyms M-LP;
Species Mus musculus
Ensembl Protein ENSMUSP00000120169
InnateDB Gene IDBG-134337 (Mpv17l)
Protein Structure
UniProt Annotation
Function Isoform 1 and isoform 3 participate in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes. {ECO:0000269PubMed:12471025, ECO:0000269PubMed:15541722}.
Subcellular Localization Isoform 1: Peroxisome membrane; Multi-pass membrane protein.Isoform 3: Cytoplasm.
Disease Associations
Tissue Specificity Isoform 1 and isoform 3 are expressed in the kidney (at protein level). Isoform 1 is expressed in the kidney, spleen, heart, brain, lung and liver. Isoform 3 is expressed in the kidney. Isoform 1 and isoform 3 expression increase during development, reache their highest level in adulthood and decrease with aging. {ECO:0000269PubMed:11327696, ECO:0000269PubMed:12471025, ECO:0000269PubMed:15541722}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2135951
InterPro IPR007248 Mpv17/PMP22
PFAM PF04117
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MS3
PhosphoSite PhosphoSite-
TrEMBL Q8CC11
UniProt Splice Variant
Entrez Gene 93734
UniGene Mm.76554
RefSeq NP_001276496
MGI ID
MGI Symbol Mpv17l
OMIM
CCDS
HPRD
IMGT
EMBL AF305634 AK034151 AK136449 AK144372 AY513273 BC037713 BC094450
GenPept AAH37713 AAH94450 AAK32113 AAS82777 BAC28608 BAE22983 BAE25854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca