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InnateDB Protein
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IDBP-535849.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ak1
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Protein Name
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adenylate kinase 1
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Synonyms
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Ak-1; B430205N08Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000123534
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InnateDB Gene
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IDBG-160744 (Ak1)
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Protein Structure
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| Function |
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also possesses broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility. {ECO:0000250, ECO:0000269PubMed:16790685}.
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| Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03171}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
4
[view]
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| Protein-Protein |
4
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
10 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:87977
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| InterPro |
IPR000850
Adenylate kinase/UMP-CMP kinase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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| PFAM |
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| PRINTS |
PR00094
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9R0Y5
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| TrEMBL |
Z4YN97
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| UniProt Splice Variant |
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| Entrez Gene |
11636
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| UniGene |
Mm.29189
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Ak1
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL772271
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| GenPept |
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Version 5.4