Version 5.4
Mus musculus Protein: Ncor1
Summary
InnateDB Protein IDBP-535872.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncor1
Protein Name nuclear receptor co-repressor 1
Synonyms 5730405M06Rik; A230020K14Rik; mKIAA1047; N-CoR; RIP13; Rxrip13;
Species Mus musculus
Ensembl Protein ENSMUSP00000121806
InnateDB Gene IDBG-184197 (Ncor1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 162 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 30 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 162 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035033 histone deacetylase regulator activity
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021794 thalamus development
GO:0031065 positive regulation of histone deacetylation
GO:0032922 circadian regulation of gene expression
GO:0040014 regulation of multicellular organism growth
GO:0042632 cholesterol homeostasis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0051225 spindle assembly
GO:0060318 definitive erythrocyte differentiation
GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0016580 Sin3 complex
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID MGI:1349717
InterPro IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain
PFAM PF00249
PRINTS
PIRSF
SMART SM00717
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q8K6
UniProt Splice Variant
Entrez Gene 20185
UniGene Mm.437515
RefSeq
MGI ID
MGI Symbol Ncor1
OMIM
CCDS
HPRD
IMGT
EMBL AL596110 BX248411
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca