InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il34

Summary

InnateDB Protein

IDBP-536116.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il34

Protein Name

interleukin 34

Synonyms

2010004A03Rik; AI593503;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114398

InnateDB Gene

IDBG-192182 (Il34)

Protein Structure

UniProt Annotation

Function

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005157	macrophage colony-stimulating factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0008284	positive regulation of cell proliferation
GO:0045087	innate immune response