Version 5.4
Mus musculus Protein: Prkci
Summary
InnateDB Protein IDBP-536149.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkci
Protein Name protein kinase C, iota
Synonyms 2310021H13Rik; AI427505; aPKClambda; mKIAA4165; Pkci; Pkcl; PKClambda; Prkcl;
Species Mus musculus
Ensembl Protein ENSMUSP00000123671
InnateDB Gene IDBG-136207 (Prkci)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004697 protein kinase C activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0008270 zinc ion binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007015 actin filament organization
GO:0010976 positive regulation of neuron projection development
GO:0016477 cell migration
GO:0032869 cellular response to insulin stimulus
GO:0034351 negative regulation of glial cell apoptotic process
GO:0034613 cellular protein localization
GO:0035089 establishment of apical/basal cell polarity
GO:0035556 intracellular signal transduction
GO:0042462 eye photoreceptor cell development
GO:0043524 negative regulation of neuron apoptotic process
GO:0045216 cell-cell junction organization
GO:0048194 Golgi vesicle budding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060252 positive regulation of glial cell proliferation
GO:0070555 response to interleukin-1
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016324 apical plasma membrane
GO:0031252 cell leading edge
GO:0043234 protein complex
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID MGI:99260
InterPro IPR000270 Phox/Bem1p
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020454 Diacylglycerol/phorbol-ester binding
PFAM PF00564
PF00130
PRINTS PR00008
PIRSF
SMART SM00666
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YXY0
UniProt Splice Variant
Entrez Gene 18759
UniGene Mm.474564
RefSeq
MGI ID
MGI Symbol Prkci
OMIM
CCDS
HPRD
IMGT
EMBL AC111093 AC117590
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca