Version 5.4
Mus musculus Protein: Alkbh1
Summary
InnateDB Protein IDBP-536202.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Alkbh1
Protein Name alkB, alkylation repair homolog 1 (E. coli)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124565
InnateDB Gene IDBG-260876 (Alkbh1)
Protein Structure
UniProt Annotation
Function Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron (By similarity). May have a role in placental trophoblast lineage differentiation. {ECO:0000250, ECO:0000269PubMed:18163532}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18163532}. Mitochondrion {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0042056 chemoattractant activity
GO:0070579 methylcytosine dioxygenase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001890 placenta development
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0031175 neuron projection development
GO:0042245 RNA repair
GO:0043524 negative regulation of neuron apoptotic process
GO:0048589 developmental growth
GO:0050918 positive chemotaxis
GO:0055114 oxidation-reduction process
GO:0070989 oxidative demethylation
GO:0080111 DNA demethylation
Cellular Component
GO:0005719 nuclear euchromatin
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:2384034
InterPro IPR004574 Alkylated DNA repair protein AlkB
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0CB42
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 654309
UniGene Mm.486235
RefSeq NP_001096035
MGI ID
MGI Symbol Alkbh1
OMIM
CCDS CCDS49120
HPRD
IMGT
EMBL CT030249
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca