InnateDB Protein
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IDBP-537082.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pdcd10
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Protein Name
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programmed cell death 10
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Synonyms
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2410003B13Rik; Ccm3; Tfa15; Tfar15;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125752
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InnateDB Gene
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IDBG-152450 (Pdcd10)
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Protein Structure
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Function |
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. {ECO:0000250, ECO:0000269PubMed:20371769}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000269PubMed:20371769}; Peripheral membrane protein {ECO:0000269PubMed:20371769}; Cytoplasmic side {ECO:0000269PubMed:20371769}. Note=Partially colocalizes with endogenous PXN at the leading edges of migrating cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
37 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1928396
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InterPro |
IPR009652
Protein of unknown function DUF1241
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PFAM |
PF06840
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VE70
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q3TVB4
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UniProt Splice Variant |
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Entrez Gene |
56426
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UniGene |
Mm.402373
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RefSeq |
NP_062719
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MGI ID |
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MGI Symbol |
Pdcd10
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OMIM |
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CCDS |
CCDS17414
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HPRD |
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IMGT |
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EMBL |
AC140430
AC168120
AF159368
AK005594
AK075926
AK077308
AK137198
AK160234
AK168857
AK169689
BC019650
BC086778
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GenPept |
AAD44335
AAH19650
AAH86778
BAB24143
BAC36058
BAC36742
BAE23263
BAE35705
BAE40678
BAE41306
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