Version 5.4
Mus musculus Protein: Tcf7l2
Summary
InnateDB Protein IDBP-537236.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcf7l2
Protein Name transcription factor 7-like 2, T-cell specific, HMG-box
Synonyms mTcf-4B; mTcf-4E; Tcf-4; Tcf4; TCF4B; TCF4E;
Species Mus musculus
Ensembl Protein ENSMUSP00000119759
InnateDB Gene IDBG-177837 (Tcf7l2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0005977 glycogen metabolic process
GO:0006006 glucose metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0014003 oligodendrocyte development
GO:0016055 Wnt signaling pathway
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030282 bone mineralization
GO:0030514 negative regulation of BMP signaling pathway
GO:0030538 embryonic genitalia morphogenesis
GO:0031641 regulation of myelination
GO:0032252 secretory granule localization
GO:0035019 somatic stem cell maintenance
GO:0035264 multicellular organism growth
GO:0035411 catenin import into nucleus
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0043588 skin development
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046621 negative regulation of organ growth
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048557 embryonic digestive tract morphogenesis
GO:0048619 embryonic hindgut morphogenesis
GO:0048625 myoblast fate commitment
GO:0048641 regulation of skeletal muscle tissue development
GO:0048713 regulation of oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:1901142 insulin metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:1202879
InterPro IPR009071 High mobility group box domain
IPR013558 CTNNB1 binding, N-teminal
PFAM PF00505
PF09011
PF08347
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z1L0
UniProt Splice Variant
Entrez Gene 21416
UniGene Mm.396897
RefSeq
MGI ID
MGI Symbol Tcf7l2
OMIM
CCDS
HPRD
IMGT
EMBL AC118695 AC137148 AC157916
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca