Version 5.4
Mus musculus Protein: Dcaf17
Summary
InnateDB Protein IDBP-537415.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcaf17
Protein Name DDB1 and CUL4 associated factor 17
Synonyms 2810055O12Rik; 4833418A01Rik; A030004A10Rik; A930009G19Rik; AI448937;
Species Mus musculus
Ensembl Protein ENSMUSP00000120016
InnateDB Gene IDBG-178371 (Dcaf17)
Protein Structure
UniProt Annotation
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus, nucleolus {ECO:0000269PubMed:19026396}. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Disease Associations
Tissue Specificity Ubiquitously expressed in the embryo, with higher expression in brain, liver and skin tissues. {ECO:0000269PubMed:19026396}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005730 nucleolus
GO:0016021 integral component of membrane
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1923013
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TUL7
PhosphoSite PhosphoSite-
TrEMBL B0R0U2
UniProt Splice Variant
Entrez Gene 75763
UniGene Mm.489700
RefSeq NP_001159452
MGI ID
MGI Symbol Dcaf17
OMIM
CCDS CCDS50601
HPRD
IMGT
EMBL AK032671 AK160679 AL929228 BC031546
GenPept AAH31546 BAC27979 BAE35954 CAM22153 CAM22154 CAM22155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca