InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem48

Summary

InnateDB Protein

IDBP-537946.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem48

Protein Name

transmembrane protein 48

Synonyms

2810475A17Rik; AI450313; Tmem48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120365

InnateDB Gene

IDBG-171596 (Tmem48)

Protein Structure

UniProt Annotation

Function

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nuclear pore complex {ECO:0000250}. Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Central core structure of the nuclear pore complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017056	structural constituent of nuclear pore

Biological Process

GO:0007129	synapsis
GO:0007283	spermatogenesis
GO:0015031	protein transport
GO:0031081	nuclear pore distribution
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly