InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncor1

Summary

InnateDB Protein

IDBP-537996.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncor1

Protein Name

nuclear receptor co-repressor 1

Synonyms

5730405M06Rik; A230020K14Rik; mKIAA1047; N-CoR; RIP13; Rxrip13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124761

InnateDB Gene

IDBG-184197 (Ncor1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 162 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	30 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	162 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0035033	histone deacetylase regulator activity
GO:0042974	retinoic acid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021794	thalamus development
GO:0031065	positive regulation of histone deacetylation
GO:0032922	circadian regulation of gene expression
GO:0040014	regulation of multicellular organism growth
GO:0042632	cholesterol homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060318	definitive erythrocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

MGI:1349717

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain

PFAM

PF00249

PRINTS

PIRSF

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q3UV08

TrEMBL

Q3UV08

UniProt Splice Variant

Entrez Gene

20185

UniGene

Mm.437515

RefSeq

MGI ID

MGI Symbol

Ncor1

OMIM

CCDS

HPRD

IMGT

EMBL

AK137695 AL596110 BX248411

GenPept

BAE23465