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InnateDB Protein
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IDBP-538295.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Usp34
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Protein Name
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ubiquitin specific peptidase 34
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Synonyms
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A530081C03Rik; Murr2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000121426
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InnateDB Gene
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IDBG-154559 (Usp34)
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Protein Structure
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| Function |
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
31 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:109473
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| InterPro |
IPR016024
Armadillo-type fold
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q6ZQ93
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| TrEMBL |
Z4YN11
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| UniProt Splice Variant |
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| Entrez Gene |
17847
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| UniGene |
Mm.119155
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Usp34
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL672004
AL672049
AL772359
AL928722
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| GenPept |
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Version 5.4