InnateDB Protein
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IDBP-538449.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lsm6
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Protein Name
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LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
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Synonyms
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1500031N17Rik; 2410088K19Rik; AI747288;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000119841
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InnateDB Gene
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IDBG-170209 (Lsm6)
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Protein Structure
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Function |
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1925901
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InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
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PFAM |
PF01423
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PRINTS |
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PIRSF |
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SMART |
SM00651
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TIGRFAMs |
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Modification |
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SwissProt |
P62313
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PhosphoSite |
PhosphoSite-P62313
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TrEMBL |
Q542U7
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UniProt Splice Variant |
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Entrez Gene |
78651
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UniGene |
Mm.415220
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RefSeq |
NP_001177933
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MGI ID |
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MGI Symbol |
Lsm6
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OMIM |
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CCDS |
CCDS40396
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HPRD |
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IMGT |
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EMBL |
AK019126
AK078392
AK141884
AK158236
AK161686
BC030427
BC098230
BC099484
CH466525
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GenPept |
AAH30427
AAH98230
AAH99484
BAB31555
BAC37251
BAE24870
BAE34418
BAE36530
EDL10862
EDL10864
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